Otoyol 52 (English: Motorway 52), abbreviated as O-52, a.k.a. Adana-Şanlıurfa Otoyolu (English: Adana-Şanlıurfa Motorway), is a toll motorway in the regions of Mediterranean and Southeastern Anatolia in Turkey, connecting the cities Adana and Şanlıurfa. The motorway is part of European route E90 and Asian Highway 84.